Stanford, a wealthy cricket impresario who lives most of the year in the Caribbean, has a personal fortune estimated by Forbes magazine at $2.2bn.
The government alleged in a federal complaint that Pendergest-Holt obstructed the investigation.
The complaint said that she "made several affirmative misrepresentations to the SEC" and failed to reveal to investigators that she was a member of Stanford International Bank's investment committee.
Bank properties seized
Brent Baker, Pendergest-Holt's lawyer, said his client was "looking forward to working with the government to get all the facts out and put this behind her".
Several governments have seized Stanford bank properties and frozen the group's assets as concern grows that the global reach of Stanford's banking operations could complicate the return of $50bn in assets belonging to at least 50,000 clients in 140 countries.
With many of Stanford's operations now in receivership it could be weeks or even months before investors and customers find out if they will be able to recover their savings and access the funds.
Pension fund's loss
In another development, Bharrat Jagdeo, the president of Guyana, said on Thursday that one of his country's pension funds lost $5.5 million deposited in Stanford International Bank.
He said that the Hand-in-Hand Trust Company, based in Houston, Texas, had invested $4 million in Certificates of Deposits on which SIB was ostensibly offering lucrative interest-rates, and $1.5 million in pension funds.
Jagdeo said that the $5.5 million amounted to nine per cent of Hand-in-Hand Trust Company's assets.
Stanford Financials customers would be unable to sell securities until the company's assets are accounted for.
Stanford Financials receiver, lawyer Ralph Janvey, said customers would be unable to make payments or transfers because the accounts have been frozen for the foreseeable future.