He’s expected to address the Rohingya refugee crisis during his trip.
The pope has previously condemned Myanmar’s treatment of the Rohingya.
More than 600,000 Rohingya have fled violence in Myanmar to Bangladesh in the past three months.
Myanmar’s ruling party has objected to the use of the term “Rohingya” to identify the mostly Muslim minority, demanding that they be called “Bengalis” or “Muslims from Bangladesh”.
Al Jazeera’s Scott Heidler reports from Yangon, Myanmar.