New trials show increased survival rates for a range of cancers

A roundup of some of the most promising announcements at a meeting of the American Society of Clinical Oncology.

Scientists have convened in the United States city of Chicago for a meeting of the American Society of Clinical Oncology (ASCO), the world’s biggest gathering of experts on cancer.

At the annual event, which wraps up on Tuesday, doctors and researchers revealed several studies that showed increased survival rates for people living with serious stages of the disease, including for lung and brain cancer.

Experts pointed to a number of scientific developments that have helped accelerate the development of new treatments by targeting the molecules produced by cancer cells.

“Essentially understanding the biology of the diseases that we’re studying has permitted us to go after druggable targets – inhibitors or blockers that can be created to go after these very specific vulnerability points,” oncologist Maryam Lustberg told Al Jazeera.

While there are many “exciting developments”, she said more in-depth research was required to “find the right treatment for the right patient at the right time”. Lustberg also pointed out that the “global disparities” in these drugs are “very alarming”, referring to the increasing inequities and barriers in accessing such treatments.

Here are some of the announcements at the ASCO meeting that have most excited experts.

Lung cancer

One of the trial results that caused a stir in Chicago has raised hopes for a new weapon against lung cancer, the deadliest of all cancers.

The treatment osimertinib was shown to halve the risk of death from a certain type of lung cancer when taken daily after surgery to remove the tumour.

Developed by the pharmaceutical group AstraZeneca, the daily pill targets patients with non-small cell cancer – by far the most common type – as well as a mutation of their epidermal growth factor receptor, or EGFR.

Iris Pauporte, head of research at France’s League Against Cancer, told AFP news agency the advance was a “big ray of hope” for treating non-small cell lung cancer, for which progress has been slow.

Muriel Dahan, head of research at Unicancer, said that if the results are confirmed, it “should change” common practice in treating this kind of cancer.

Systematic testing for the EGFR mutation would also become necessary for lung cancer patients, she added.

Brain cancer

Another treatment, called vorasidenib, was found to significantly prolong the progression-free survival of patients with brain tumour glioma, according to clinical trial results.

The daily pill, developed by French pharma firm Servier, aims to block an enzyme responsible for the progression of some brain cancers that have been particularly difficult to treat.

Patrick Therasse, Servier’s vice-president of oncology research, told AFP that there “have been few therapeutic advances for brain tumours over the last 20 years”.

“Thanks to our targeted treatment, patients avoided cancer progression for 27.7 months, compared to 11.1 months” for those taking a placebo, he added.

Close-up of female doctor looking at CT scan report on computer monitor. Surgeon with pen viewing at X-ray image on computer screen in hospital.
Vorasidenib was found to significantly prolong the progression-free survival of patients with brain tumour glioma [Getty Images]

Fabrice Andre, head of research at France’s Gustave Roussy cancer centre, said  “precision medicine opens a door for a disease for which there was nothing until now”.

“It means that science can unblock situations that were catastrophic,” he told AFP.

Unicancer’s Dahan said it was important to “remain cautious” but added that “this could become the new therapeutic standard – depending on further trials”.

Breast cancer

Preliminary trial results also released in Chicago indicated the drug ribociclib reduced the risk of breast cancer recurring by 25 percent for a large group of early-stage survivors.

The drug, developed by Swiss pharmaceutical maker Novartis, is already widely approved around the world. It was tested in combination with hormonal therapy.

ASCO expert Rita Nanda said it was a “very important and practice-changing clinical trial”.

Cervical cancer

There was also good news for patients with early-stage cervical cancer with a low risk of progression.

There was no greater risk of the cancer returning for patients who get a simple hysterectomy, in which the uterus and cervix are removed, than a radical hysterectomy, in which the uppermost part of the vagina is also removed, according to phase three trials.

The League Against Cancer’s Pauporte said this was “good news”, adding that “it shows that it’s not just progress involving drugs that was important”.

Ovarian cancer

A trial also presented at ASCO showed that taking the antibody treatment mirvetuximab soravtansine significantly improved the survival rate of patients with ovarian cancer, a particularly deadly form of cancer.

ASCO expert Merry Jennifer Markham said the treatment “demonstrates progress and offers hope for these patients”.

Rectal cancer

Study results released in Chicago indicated that patients with locally advanced rectal cancer could receive chemotherapy without getting radiation therapy before undergoing surgery.

This would spare patients from the side effects of radiation, which can include fatigue, blurry vision, headaches, and nausea.

FILE - In this Aug. 28, 2006 file photo, a doctor holds a vial of the human papillomavirus (HPV) vaccine Gardasil in his Chicago office. A national estimate suggests that nearly half of U.S. men have mostly silent infections caused by the sexually-transmitted human papilloma virus, and that 1 in 4 has strains linked with several cancers. The study was released Thursday, Jan. 19, 2017. (AP Photo/Charles Rex Arbogast, File)
A doctor holds a vial of the human papillomavirus (HPV) vaccine Gardasil [File: Charles Rex Arbogast/AP Photo]


Vaccines that treat existing cancer have long been a goal of the medical community.

Preliminary studies announced at the ASCO meeting involved vaccines targeting lung cancer, head and neck cancers, brain tumour glioblastoma and the cancer-causing HPV virus.

Christophe Le Tourneau, an oncologist at France’s Curie Institute, which presented a study about a vaccine for a certain form of HPV, said there has been “significant technological progress” in the area recently.

“Therapeutic vaccines, we talk about them more and more, and there are more and more trials in progress,” he said.


Source: AFP, Al Jazeera