Al-Aqsa Martyrs Brigades, a radical offshoot of Palestinian leader Yasir Arafat’s mainstream Fatah group, claimed responsibility for the strike.
The explosion, which killed the bomber, took place on Thursday near the occupied West Bank city of Tulkaram, according to occupation military sources.
The blast seriously wounded one Israeli and lightly injured another. A Palestinian bystander was also hurt, paramedics said.
According to radio reports, the attacker walked up to an office at an Israeli army base near the town where Palestinians apply for humanitarian permits to cross roadblocks and set off the explosion.
Elsewhere occupation forces opened fire on stone-throwing children, critically injuring a 12-year-old boy in the occupied West Bank city of Qalqilya late on Wednesday.
Three Israeli soldiers were also wounded when resistance fighters opened fire on their vehicle on Wednesday evening near the West Bank city of Nablus.