Bacteria makes film debut

Researchers say they have created photographs of themselves by programming the notorious E coli bug - best known for outbreaks of food poisoning - to make pictures.

    The E coli bacteria was used to produce an image

    The scientists at the University of California, San Francisco, and at the University of Texas have said the process works in much the same way as a Kodak film produces images, the journal Nature reported on Wednesday.


    It is the latest advance in "synthetic biology", a disputed research movement launched mostly by engineers and chemists bent on genetically manipulating microscopic bugs into acting like tiny machines, creating powerful and inexpensive ways to make drugs, plastics and even alternatives to fossil fuel.


    The field seeks to go beyond traditional genetic engineering feats where a single gene is spliced into bacteria and other cells to manufacture drugs. Synthetic biologists are trying to create complex systems that function as logically and reliably as computers.


    Mainstream biologists, however, scoff that biology - life itself - is too unpredictable and prone to genetic mutation to understand, let alone tame and turn into miniature factories.


    Bioethicists fret that synthetic biologists are trying to create living creatures and are inventing technology that can readily be used by terrorists.


    New frontiers


    Still, a growing number of engineers are jumping into the nascent field, whose chief goals include breaking down microbes and other living things into smaller components and reassembling those parts into useful machines.


    "There is kind of a hacker culture behind all of this," said Chris Voigt, a University of California, San Francisco, researcher who, at 29, was the senior author on the bacteria-as-film paper in Nature.


    Voigt and colleagues took from algae light-sensitive genes that emit black compounds and spliced them into a batch of E coli bacteria. The organisms were spread on a petri dish that resembles a cookie sheet and placed in an incubator.


    A high-powered projector cast photographic images of the researchers through a hole on top of the incubator, exposing some of the bacteria to light.


    The result: Ghostly images like traditional black-and-white photographs of the researchers responsible for the invention, at a resolution Voigt said was about 100 megapixels, or 10 times sharper than high-end printers.


    The work, though, is not intended for commercial markets. "They aren't going to put Kodak out of business any time soon," said Massachusetts Institute of Technology researcher Drew Endy, a leading synthetic biologist.


    Instead, the creation will be used as a sensor to start and stop more complex genetic engineering experiments. The idea is to create a genetically engineered cell that lays dormant until a laser is shined on it.


    Such an accomplishment would add to a field that is making strides around the world, in such projects as:


    - Scientists in Israel made the world's smallest computer by engineering DNA to carry out mathematical functions.


    - J Craig Venter, the entrepreneurial scientist who mapped the human genome and launched the Rockville, Md-based research institute named after himself, is trying to create novel organisms that can produce alternative fuels.


    Ethical issues


    Some ethical issues are cropping up.


    It is cheap and easy to buy individual genes online. They cost about $1 each, down from the $18 apiece charged just a few years ago. Researchers last year created a synthetic polio virus by simply stitching together these mail-order genes.


    National security experts and synthetic biologists themselves are concerned that rogue scientists could create biological weapons, such as like deadly viruses that lack natural foes. They worry about innocent mistakes: organisms that could potentially create havoc if allowed to reproduce outside the lab.


    Researchers are casting about for ways to self-police the field. Leaders in the field have organised a second national conference to grapple with these issues this May, and the Arthur P Sloan Foundation in June handed out a $570,000 grant to study the social implications of the new field.


    "This is powerful work and we live in an age that many tools and technologies can be turned into weaponry," said Laurie Zoloth, a bioethicist at Northwestern University.


    "You always have the problem of dual-use in every new technology. Steel can be used to make sewing needles or spears."

    SOURCE: Agencies


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