Imran Khan, the leader of the Pakistan Tehreek-e-Insaf (PTI) party, is a vocal critic of the US war in Afghanistan, and has called for his country to delink itself from its ally.
With a presidential election due in the US, Al Jazeera spoke to the Pakistani opposition leader about what prospects he felt there were for the relationship were Barack Obama to be re-elected, or if Mitt Romney were to assume the US presidency.
Khan has previously said that he would order the Pakistani armed forces to shoot US drones down if he were to become prime minister.
He has also said that, if his party is brought to power in Pakistan's next elections, he will reset the Pakistan-US relationship, pulling away from any military alliance with the country.
Al Jazeera's Dareen Abughaida interviewed him via video link from Islamabad.