France captain Thierry Dusautoir has been ruled out of the Six Nations with a torn bicep.
The 32-year-old flanker, who has won 65 international caps, ruptured a biceps tendon during Toulouse's Heineken Cup victory against Zebre on Saturday.
Dusautoir, who has 65 caps, managed to make it through the entire game but scans on Sunday revealed the severity of the injury.
"He will be out of action for four months," Toulouse coach Guy Noves was quoted as saying on the website of French newspaper L'Equipe.
"His injury adds to a growing list of serious injuries to key players. That makes it five to six players of the highest quality that we have lost."
There was another blow for Saint-Andre when Perpignan winger Sofiane Guitoune was seriously injured in their 36-18 defeat by Gloucester on Sunday.
Guitoune ruptured his Achilles and manager Marc Delpoux said he would be undergoing surgery on Monday.
France, who finished bottom of the Six Nations last year, host England in their opening match on February 1.
Source: Al Jazeera and agencies