Detroit's Tomas Jurco and Gustav Nyquist scored twice in a 1:42 span in the third period, and goal-tender Jimmy Howard made 33 saves, to give the Red Wings a 3-2 come-from-behind win over the Boston Bruins.
The loss snapped Boston's franchise-record nine-game road unbeaten streak and was the Bruins' first regulation loss in 17 games (15-1-1).
Elsewhere, a power-play goal by Casey Cizikas with 10:29 left in the third period proved to be the difference as the Islanders handed Ottawa a 2-1 defeat that further damaged what slim hopes the Senators had left of making the playoffs.
Tanner Pearson and Jeff Carter scored a goal and an assist and goaltender Jonathan Quick made 17 saves as the Los Angeles Kings defeated Phoenix 4-0 to clinch a playoff berth.
The win clinched a playoff spot for the Kin-gs (45-26-6) for the fifth consecutive year.
Defenceman Francois Beauchemin scored the winning goal with 1:21 left and the Anaheim Ducks rallied for a 3-2 victory over the Edmonton Oilers.