Colombia are without their star player Radamel Falcao, who scored nine goals in 13 qualifying matches, who is ruled out of contention with a knee injury.
In the absence of Falcao the likes of James Rodriguez, Juan Fernando Quintero and Juan Cuadrado are likely to shoulder the burdon of driving their team forward in a match that they will be favourites to win.
Greece recorded a win and two draws in three World Cup warm-up games and will look to play with a focus on defence and frustrating their opponents.
Greece will look to Kostas 'Pistolero' Mitroglou, who has and has eight international goals and is a firm fan-favourite at home.
Young Borussia Dortmund defender Sokratis Papasthopoulos will be expected to lead the Greek defence.
- Colombia have lost eight of their 13 World Cup matches (W3, D2)
- However, Los Cafeteros had more shots on target (99) than any other team in South American qualifying
- Greece have lost both previous World Cup encounters with sides from South America, conceding six in the process
Venue: Estadio Mineirao
Colombia (Possible, 4-4-2): Ospina; Zuniga, Yepes, Zapata, Armero; Cuadrado, Aguilar, Rodriguez, Sanchez; Gutierez, Martinez.
Greece (Possible, 4-4-2): Karnezis; Torosidis, Papasthathopoulos, Manolas, Holebas; Salpingidis, Katsouranis, Maniatis, Kone; Samaras, Mitroglou.
Referee: Mark Geiger (USA).
Source: Al Jazeera