Leaders Barcelona struck a potentially decisive blow in the Primera Division title race when Lionel Messi scored twice in a 4-1 win at home to second-placed Atletico Madrid to move nine points clear at the top on Sunday.
The victory moved Barca 13 points ahead of ailing champions Real Madrid, who were surprisingly held to a 2-2 draw at home by lowly Espanyol.
Tito Vilanova's unbeaten leaders fought back after Radamel Falcao gave Atletico a deserved lead. A magnificent strike from Adriano levelled the scores, and Sergio Busquets and a second-half brace from Messi completed the scoring.
Barca have 46 points from 16 games, Atletico have 37 and Real 33.
"You can't say the league is over," Real midfielder Xabi Alonso told Spanish television after their earlier game.
"We will continue fighting, it will be tough, but we will carry on."
Atletico made an impressive start, causing problems on the break, and after twice going close, Colombia striker Falcao put the visitors ahead in the 32nd minute with his 17th of the campaign.
Diego Costa stole the ball off Messi and fed Falcao who sped away and cleverly lobbed the advancing Victor Valdes.
Five minutes later, Barca were back in the game thanks to a thunderous shot from Adriano, who cut in from the right flank and fired in off the underside of the crossbar.
Atletico were struggling to break out of the area before halftime, and when they failed to clear a corner, Busquets calmly stroked home the second.
After the break, Messi slotted a third into the corner and then pounced on an error at the end for his 25th in the Primera Division and 90th for club and country in 2012.
Espanyol substitute Juan Albin stunned Real with an 88th-minute equaliser as the Barcelona-based side grabbed an unlikely draw at the Bernabeu.
The Uruguayan forward bundled the ball in after Real failed to clear a corner, and whistles rang around the ground as the teams filed off the pitch at the end.
Karim Benzema was left in the stands with an ankle injury, and Cristiano Ronaldo started in the centre-forward position, but for all their possession Real struggled in the first half.
Visiting striker Sergio Garcia, a Euro 2008 winner with Spain, sprinted clear to net past Iker Casillas in the 31st minute.
Luka Modric crashed a shot against the post, but just as the Bernabeu was getting restless Sami Khedira crossed and Ronaldo stuck out a foot to level in the 45th minute.
Ronaldo's reverse pass picked out Fabio Coentrao's driving run, and the Portugal defender put Real ahead with his first league goal for the club, soon after the re-start.
A fingertip save and the woodwork prevented a quick third for Real, but Espanyol continued to threaten and Albin made them pay for failing to finish off the job.
Earlier, Rayo Vallecano scored a late penalty to spoil Ernesto Valverde's home debut as Valencia coach, with a surprise 1-0 victory.
Valverde was brought in as a replacement for the sacked Mauricio Pellegrino two weeks ago and has overseen victories away at Osasuna in the league and in the King's Cup, but his side offered little for the demanding Mestalla crowd.
After an evenly-balanced contest with few chances, home defender Tino Costa needlessly hauled down Roberto Trashorras in the area for a penalty in the 83rd minute.
Rayo's Alejandro Dominguez stepped up to score from the spot, and the home fans whistled and chanted against club president Manuel Llorente in the closing minutes.
Valencia's objective is a return to the Champions League, where they have already reached the last 16 this season, but they lie seven points adrift of fourth-placed Malaga in 11th place with 21 points.
City neighbours Levante were above them in fifth with 27 points after a 1-0 win at Real Zaragoza earlier in the day.
Juan Ignacio Martinez's side gained a measure of revenge for their defeat by the same scoreline at home to Zaragoza in a King's Cup last-16 first leg during the week.
Ruben Garcia gave the visitors the lead after 19 minutes and their notoriously solid defence stood firm thereafter.