Defending champions Juventus scored a stoppage-time winner to beat Bologna 2-1 on Wednesday and extend their unbeaten Serie A run to 49 games.
Paul Pogba headed in the winner to cap an excellent game from the young midfielder, who showed exactly why Manchester United were so desperate to keep him before his move to Italy in the offseason.
Fabio Quagliarella put Juventus in front in the 54th minute, but Bologna midfielder Saphir Taider levelled in the 71st.
It was the Turin-based giants' ninth win in 10 domestic league games and another victory to add to their terrific run. However, Pogba's winner came in the dying seconds and for a while did not look like coming.
Juventus are now four points ahead of closest rivals Inter Milan after Andrea Stramaccioni's side recorded their sixth succesive victory, beating 10-man Sampdoria 3-2. Inter went a goal behind but second half-goals from Diego Milito, Rodrigo Palacio and Fredy Guarin gave them the win.
It sets up a mouthwatering clash between the two bitter rivals this weekend.
Juventus are closing in on AC Milan's record of 58 Serie A games unbeaten, set over the 1990-91, 91-92, and 92-93 seasons.
Napoli fell below Inter, and six points behind Juventus, after losing 1-0 to Atalanta. Carlos Carmona scored in the 64th minute to inflict Napoli's second defeat of the season.
Lazio are fourth in the league behind Napoli, and nine points behind Juventus, after a 1-1 draw against Torino. Kamil Glick headed Torino into an early lead but Stefano Mauri levelled shortly before the hour mark.
Topsy-turvy AS Roma, who have the best attacking and worst defensive records in the league, scored first but lost 3-2 at Parma.
The irrepressible Antonio Di Natale was again on form for Udinese scoring twice, including a last-gasp equaliser in a 2-2 draw with Catania. Lucas Castro and Francesco Lodi scored for Catania.
Cagliari celebrated their biggest win of the season when they beat Siena 4-2 to consolidate their mid-table position, while second-from-bottom Chievo grabbed only their third win of the season with a 2-0 defeat of Pescara.