Lakers guard Kobe Bryant scored a game-high 39 points with nine rebounds but Gerald Green came off the bench to score 26 points as Phoenix beat Los Angeles 112-106.
The Lakers, who are 0-5, are off to their worst start since the club moved to Los Angeles for the 1960-61 season.
Elsewhere, Guard Damian Lillard produced a game-high 27 points plus seven assists and six rebounds to lead the Trail Blazers to a 101-82 win over the Cavaliers.
Portland also got 21 points and six rebounds from guard Wesley Matthews. Center Robin Lopez added 19 points on 8 for-11 shooting to go with six rebounds.
James Harden came within one rebound of a triple-double as the Houston Rockets remained undefeated by beating the previously perfect Miami Heat 108-91.
Harden finished with 25 points, 10 assists and nine rebounds.
Guard DeMar DeRozan scored 16 points and forward Patrick Patterson added 14 as Toronto defeated Oklahoma City 100-88.
Bulls 98, Magic 90
Pelicans 100, Hornets 91
Wizards 98, Knicks 83
Bucks 87, Pacers 81