David Ortiz hit the 452nd and 453rd home runs of his career, moving past Boston great Carl Yastrzemski into 36th place on the all-time list as the Red Sox won their fifth straight game, routing the Toronto Blue Jays 14-1.

Right-hander John Lackey (11-6) allowed two hits, no walks and one run in seven innings to earn the win in the opener of a four-game series between American League East rivals.

The pair of two-run homers by Ortiz, both against left-handed reliever Brad Mills, took the Red Sox (47-52) designated hitter past former Red Sox left fielder Carl Yastrzemski into 36th place on the all-time home run list with 453.

Other results:

Orioles 4, Angels 2

Tigers 4, Diamondbacks 3

Mariners 5, Mets 2

Brewers 5, Reds 2

Giants 7, Phillies 4

Dodgers 5, Pirates 2

Nationals 7, Rockies 2

Marlins 3, Braves 1 (10 innings)

Rangers 4, Yankees 2

White Sox 3, Royals 1

Twins 4, Indians 3

Source: Agencies