Berdych was understandably delighted with the result.
"Through all my career matches, this one was the toughest one to close up ... against Roger [on] centre court in Wimbledon. It was pretty nice," he said, after becoming the first Czech man to reach the last four since Ivan Lendl in 1990.
After the 6-4, 3-6, 6-1, 6-4 victory, Berdych advanced to the semi-final where he will meet Novak Djokovic, who defeated Lu Yen-hsun, the son of a Taiwanese chicken farmer, in straight sets.
Berdych has played Djokovic twice in his career and lost on both occasions but said that the past would not affect the upcoming game.
"It's going to be different. It's going to be similar to the match against [Andy] Murray I played at Roland Garros, we played before like a really long time ago, and then the match is completely like we met for the first time."
On the other side of the draw, Murray defeated Frenchman Jo Wilfreid Tsonga by three sets to one, keeping home fans' hopes of a British player winning the first men's title for 74 years alive.
He will meet Rafael Nadal, the 2008 champion, for a much-anticipated semi-final clash after the Spaniard came from a set down to defeat Robin Soderling three sets to one.