Chelsea midfielder John Obi Mikel will serve a three-match ban after the Football Association rejected his appeal against the red card he received against Manchester United.
Mikel was sent off in the first half of Sunday's 2-0 loss at Old Trafford for what referee Mike Dean said was a two-footed challenge on United defender Patrice Evra.
Chelsea appealed, saying the challenge was not two-footed, but the FA chose to back Dean's original decision.
In further drama for the Blues, captain John Terry could also face an FA charge for trying to take the red card from Dean when he brandished it at the Nigerian midfielder.
Television footage showed Terry grabbing at the card and British newspapers said Dean had mentioned the incident in his match report to the FA.
The England captain could be fined or even banned over the incident.
Meanwhile, Wayne Rooney will play in Wednesday's third-round match against Coventry.
Rooney, who would normally sit out such fixtures, has only played two games after recovering from a broken foot and is keen for more playing time.
"Wayne Rooney's been in my ear wanting to play," Manchester United manager Alex Ferguson said.
"He wants to play, he wants to be the captain, he wants to take the penalties, the corners, the free kicks, the goal kicks, the lot."
Rooney has only played four times this season, two Premier League matches, one Champions League game and the preseason Community Shield.