The glamour Japanese outfit were forced to settle for a draw themselves as substitute Budi Darsono scored a late goal to earn Indonesia's Persik Kediri a 3-3 draw with Japanese league champion in the other Group E match.
Playing at the Manahan Stadium in the Central Java town of Solo, the host team led 2-1 in the first half.
The first goals for both team came from penalties with midfielder
Shinji Ono giving the visiting Urawa Reds an early lead in the 9th minute
before Uruguayan forward Christian Gonzalez scored the equalizer in the 23rd.
Gonzalez scored his second goal eight minutes later for the hosts with a
half volley off a pass from the right flank.
The visitors intensified their attack after the break resulting in a goal from midfielder Robson Ponte in the 50th minute when he scored off a long pass.
Midfielder Yuki Abe put Urawa ahead 3-2 in the 62nd minute, heading home a corner kick from Robson.
But 16 minutes later, Darsono scored the last goal to salvage the draw.
Each team still have one preliminary match remaining on May 23, when Persik take on Shanghai Shenhua of China and Urawa host Sydney FC.
Seongnam Ilhwa defeats Dong Tam Long An
A late goal by defender Park Jin-sub helped South Korea's Seongnam Ilhwa to a 2-1 win over Vietnam's Dong Tam Long An in Group G.
Striker Mota put the South Korean champions ahead in the 17th minute with a powerful shot from 25 meters.
Skipper Phan Van Tai Em leveled for the Vietnamese side in first-half
injury time with a close range volley off Congolese striker Kabanga
Park sealed the win for Seongnam five minutes from fulltime with a shot
from 18 meters.
Seongnam, with 10 points, trails China's Shandong by three points heading into the final round robin match.
The Vietnamese champion Dong Tam Long An are eliminated from quarterfinals contention, along with Australia's Adelaide United.
Kawasaki reach quarterfinals
Kengo Nakamura scored two goals to power Kawasaki Frontale past Arema Malang of Indonesia 3-0 as the Japanese side became the first team to advance to the Asian Champions League quarterfinals.
Nakamura scored in the 4th and 70th minutes before Taku Harada sealed the victory with a goal 10 minutes from fulltime at Todoroki Stadium.
With the win, Frontale took an unassailable six point lead in Group F ahead of the final round of round robin matches.
Frontale has 13 points after five games, ahead of South Korea's Chunnam on seven, Arema Malang on four and Bangkok University on three.
They are the first Japanese team to ever advance to the knockout stage
of the Asian Champions League.
Frontale joins Chonbuk Motors in the quarterfinals.
The South Korean team qualified for the final eight automatically as defending champions.