|Angered by repeated incursions by Nato helicopters, Pakistan has blocked a key supply route [Reuters]
Disputes over how the US is fighting its war on terror in Pakistan have put the two nations at odds once again.
A tentative agreement has been made to conduct a joint investigation into a Nato helicopter airstrike that killed three Pakistani soldiers on Thursday in the country's Kurram region.
In the days following the incident, more than a dozen Nato fuel trucks traveling through Pakistan were reportedly torched by armed men.
Islamabad also responded by blocking off a key supply route used by the US-led coalition forces in Afghanistan.
In recent months, the CIA has also increased its drone attacks in Pakistan's border areas, which Islamabad has condemned as a violation of its sovereignty.
On Monday's Riz Khan we ask: Have rising tensions in US-Pakistan relations reached a breaking point?
Anand Naidoo speaks to Talat Masood, a retired Lieutenant General in the Pakistan army, and Christine Fair, a political scientist and assistant professor at Georgetown University's Center for Peace and Security Studies.
You can join the conversation. Call in with your questions and comments on Monday, October 4, 2010 at our live time of 1630GMT. Repeats air at 2130GMT, and the next day at 0230GMT and 1130GMT.