For David Cameron, the British prime minister, it has been a hectic year with his government rocked by the phone-hacking scandal, which raised questions about Cameron's decision to employ a former editor of Murdoch's as his communications director. And in addition to that the PM has to deal with the situation in Libya, Syria and Afghanistan.
Cameron talks about the tragedy of 9/11, the so-called war on terror, the impact of the Arab Spring, the military intervention in Libya, the security situation in Afghanistan and the recognition of Palestine as a state.
September 11, 2001 became the day that really shook the world and changed not only American but international security policy forever.
Sir David speaks to Michael Chertoff, who on that day led the US government's response to the attacks and helped to trace the hijackings to al-Qaeda.
Chertoff describes how the 9/11 attacks changed global security, the challenges of counter-terrorism, the killing of Osama bin Laden and the current state of al-Qaeda.
Drought in the Horn of Africa
It has been described as the worst drought in 60 years. In the Horn of Africa, Somalia, Ethiopia and Kenya have seen crop failures, lifestock deaths and a resulting famine. The worst affected area is in Somalia, which is hard for aid agencies to reach as it is being controlled by the Islamic al-Shabab group.
Barbara Stocking, Oxfam's chief executive, recently returned from a visit to the region and speaks to David Frost about the situation in the Horn of Africa, the conflict in Somalia and challenges facing aid agencies.
On September 20, the UN General Assembly will be asked to vote on whether Palestine should be recognised as a state and be granted full UN membership. For some this would be a massive victory, for others a diplomatic tsunami and for others an irrelevance.
Sir David is joined by Mehdi Hasan, a senior editor at the New Statesman, who speaks about Palestinian rights and the impact of the UN vote on the peace process.