Amr Moussa, the Arab League chief, said at the conference that both the Palestinians and Israelis were to blame for the latest violence that has plunged Gaza into chaos.
He said: "It doesn't mean that the Palestinians aren't responsible because they shouldn't have resorted to ... bloodshed.
"Compounded with the Israeli occupation and the violence against them and without hope that a state is coming, what do you expect?"
About 1,000 participants from 50 countries worldwide are attending the meeting that has adopted "putting diversity to work" as its main theme to spotlight "efforts to accelerate economic diversity".
Dubbed the "Davos of the Middle East," the meeting in Jordan will cover several sessions on political development in the Middle East, as well as on conflicts and violence in the region.
Arab security force
Meanwhile, a political adviser to Ismail Haniya, the Palestinian prime minister, has revealed that Arab leaders are in talks on a possible Arab security force to control the internal situation in Palestine.
Ahmed Yousef told Al-Quds Al-Arabi newspaper that Arab countries were in direct contact with each other over the issue.
Separately, Farouq al-Qaddoumi, head of the political department at the Palestinian Liberation Organisation, has told Al Khaleej newspaper that elements of the Hamas movement are trying to disrupt the Mecca agreement.
"Recent events are evidence of this phenomenon which is repeated between one agreement and another," he told the UAE newspaper.
Al-Qaddoumi also said that the central leadership of Hamas in Damascus was sincere in its commitments, but the keadership in Gaza, led by Mahmoud al-Zahhar, is seeking to control the Gaza Strip through violence.