Radovan Karadzic, the former Bosnian Serb leader, questioned the right of the UN war crimes tribunal for the former Yugoslavia to try him, right from the start of the trial.
Since then, he has used every opportunity to delay proceedings but the court has told him he must now begin his defence to some of the most serious charges of war crimes anyone has faced since the second world war.
Al Jazeera's Erica Wood reports.
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