When she takes over from Japan's Koichiro Matsuura - should her appointment be endorsed in October by Unesco's 193-member assembly - she will become the first woman to lead the UN body and the first from eastern Europe.
Nine candidates were in the running for the senior job at Unesco when the body's council began voting last Thursday, but seven dropped out one-by-one.
Delegates had been split over the two remaining candidates, with Hosni, Egypt's minister of culture, facing accusations that he is an anti-semite.
Hosni caused concern among some observers after he was quoted as saying he would burn Hebrew-language books.
Hosni has insisted his comments were part of an angry exchange in parliament with hardliners from the Muslim Brotherhood and were taken out of context.
He has also been associated with media censorship in his home country and sparked anger among Muslim groups there when he said the hijab was a "step backward" for Egyptian women.
Supporters of Hosni said his election would have sent a positive signal from the West to the Muslim world, pointing to Hosni's efforts to rebuild a crumbling old synagogue in Cairo, Egypt's capital.
But his critics say that the comments he made last year made him unfit for the role.
Hosni's detractors include Elie Wiesel, an Auschwitz death camp survivor and Nobel laureate, who said the global cmmunity would be shamed if he was appointed.