At least 10 people have been killed after a suspected US drone fired missiles into Pakistan's North Waziristan region, Pakistani intelligence agency officials have said.
The raid on Friday on Darpa Kheil village was the third such attack this month in Pakistan's ethnic Pashtun tribal areas by what are believed to be CIA-operated pilotless aircraft.
"The attack caused a huge explosion," said a Reuters reporter in Miranshah, about 2km from the scene of the raid.
Drones were seen flying over the area after the blast, he said.
Darpa Kheil village is home to a large madrassa, or religious school, set up by Jalaluddin Haqqani, a former veteran Afghan fighter commander who is also a senior Taliban leader.
US drone aircraft attacked the complex in September last year, killing 23 people, most of them members of Haqqani's family.
Pakistani and US officials believe Baitullah Mehsud, the Pakistani Taliban chief, was killed in a similar strike in neighbouring South Waziristan on August 5.
Pakistan, an ally of the US, which is fighting al-Qaeda and Taliban fighters in the region, officially objects to US drone attacks on its soil, saying they violate its sovereignty.