Fry surgically removed a venom gland from a terminally ill Komodo at Singapore Zoo for the study, and said it contained a toxic poison which would induce strong stomach cramps, hypothermia and a drop in blood pressure.
He also said the venom also blocked the ability for blood to clot.
"Such a fall in blood pressure would be debilitating in conjunction with blood loss and would render the envenomed prey unable to escape," Fry told the AFP news agency.
"These results are congruent with the observed unusual quietness and apparent rapid shock of prey items."
Komodos are the world's heaviest lizard, weighing at around 100kg and growing up to three metres in length.
They are native to several Indonesian islands and are considered a vulnerable species, with only a few thousand left in the world.
They live on a diet of large mammals, reptiles and birds but have been known to attack humans.