"Nobody and no party is behind us," Ko Htin Kyaw, a mechanical engineer, told Reuters before police dispersed the crowd.
Some of the protesters were taken away.
Public protests are rare in Myanmar, which has been ruled by the military in various guises since 1962.
Despite being blessed with natural wealth in oil, gas and minerals, four decades of mismanagement have left the economy in a mess and the country's 52 million people among the world's most impoverished.