The Federal Reserve decided to trim its bond purchases by another $10bn as it stuck to a plan to wind down its extraordinary economic stimulus despite recent turmoil in emerging markets.
The action was widely expected, although some investors had speculated that the US central bank might put its plans on hold given the jitters overseas.
Fed Chairman Ben Bernanke, who hands the Fed's reins to Vice Chair Janet Yellen on Friday, managed to adjourn his last policy-setting meeting without any dissents from his colleagues.
It was the first meeting without a dissent since June 2011 - a sign of how tumultuous Bernanke's tenure has been.
In addition to proceeding with plans to scale back its bond buying, the Fed made no changes to its other main policy plank: its pledge to keep interest rates low for some time to come.
The decision suggests that it would take a serious threat to the US economy before the Fed backs down from a resolve to shelve the asset-purchase programme later this year.
Indeed, it offered a somewhat rosier assessment of the US economy's prospects than it did last month, saying "economic activity picked up in recent quarters".
It also largely shook off surprisingly soft jobs growth in December. "Labor market indicators were mixed but on balance showed further improvement," it said.
"They really want to move to the sidelines here and get out of the (bond buying) business," said Jack Ablin, chief investment officer at BMO Private Bank in Chicago.
All 17 top Wall Street economists polled by Reuters news agency on Wednesday expect the Fed to wind the programme down by year's end, and nearly all believe the Fed will not raise rates until at least the third quarter of 2015.
Major US stock indexes closed down more than 1 percent, while yields on the benchmark 10-year Treasury note hit the lowest level since late October.
The dollar rose against the euro but was little changed against a broad basket of currencies.
Ending the purchases
Importantly, the Fed stuck to its promise to keep rates near zero until well after the US unemployment rate, now at 6.7 percent, falls below 6.5 percent, especially if inflation remains below a 2 percent target.
Some analysts had speculated it might alter this guidance, given how close the jobless rate now is to the rate-hike threshold.
In fact, the central bank's statement largely mirrored the one it issued after its December 17-18 meeting, when it announced an initial $10bn cut to its monthly bond purchases.
At the time, Bernanke told reporters the Fed would likely continue to taper the purchases in measured" steps through the year until it was fully wound down, as long as the economy continued to heal.
He did not speak to the media on Wednesday.
In its statement on Wednesday, the Fed said it would buy $65bn in bonds per month starting in February, down from $75 billion now.
It shaved its purchases of US Treasuries and mortgage bonds equally.
"The Fed's action today represents a continuation of its resolute determination to end (bond purchases) during 2014," said Daniel Alpert, managing partner at Westwood Capital in New York.
"The policy has hit its 'sell by' date."