He was often gripped by paranoid delusions and in one episode in 1982, while filming Jungle Warriors in Mexico, he ran naked into the jungle, convinced World War Three had started.
|Hopper, centre, alongside Peter Fonda and Jack Nicholson in 1969's Easy Rider [AP]
He was put on a plane home but jumped out onto the wing as it was about to take
off, fearful that the plane was on fire.
Upon his return, he was admitted to a psychiatric hospital for three months.
He was nominated for two Oscars: The first for co-writing the script for Easy Rider and the second was for his role in the 1986 drama Hoosiers.
But Hopper considered his role as a psychotic villain in David Lynch's Blue Velvet to be the finest performance of his career.
The quintessential Hollywood hellraiser, he gained a reputation as a talented but erratic performer because of his tantrums and abuse of alcohol and drugs.
On the set of True Grit, Hopper was said to have so enraged John Wayne that the star reportedly chased Hopper with a loaded gun.
Hopper became ill last September but continued working up until his death.