Timothy Geithner, the US treasury secretary, members of congress, regulators and representatives from the financial industry and consumer groups will also attend the event.
Obama is also expected to call for the establishment of an independent consumer financial products watchdog agency, and for requiring financial firms to hold more capital so they can better survive tough times.
The plans would impose more transparency and accountability for more exotic financial markets that in recent years expanded far beyond the government's ability to keep track of them.
Strong oversight of financial firms, with more and better capital reserves – includes a new Financial Services Oversight Council
Stronger regulation of core markets and market infrastructure, including regulation of credit agencies and credit default swaps
Strengthened consumer protection - consumers to have greater transparency, simplicity, fairness, accountability, and access to fair lending law
New government tools to aid financial crises
Higher standards internationally
The government would also be given the power to seize and dismantle large, troubled companies that are not banks, much as the US Federal Deposit Insurance Corporation does at present.
The administration will also urge curbing markets for securitised debt and over-the-counter derivatives, as well as more regulation of money market mutual funds, credit rating agencies and hedge funds.
There are also plans to urge changes in corporate governance that could give shareholders more power to restrain executive compensation.
The US Office of Thrift Supervision - a federal bank regulator and superviser - will be abolished under the reform proposals, US officials also said.
The agency was heavily criticised following the near collapse of insurance AIG, the US insurance giant, which was bailed out by the government for $180bn; the failure of Washington Mutual, the biggest bank to fail in US history; and the collapse of investment banking giant Lehman Brothers last September.
Following the announcement the proposals will be debated in US congress. Already committees of both the senate and the House of Representatives have scheduled more than a dozen hearings on regulatory reform between now and mid-July.
Republicans in the House, meanwhile, have already offered their own rival plan.
Obama earlier rejected criticism that the proposals meant excessive government interference in the business world, saying he would still see a "relatively light touch".
"[It is] puzzling to hear the standard conservative critique of what we're doing, when essentially every step we're taking involves cleaning up the mess that we found when we arrived here at 1600 Pennsylvania Avenue [the White House]," he told the Wall Street Journal on Wednesday.