President Barack Obama has lifted US economic sanctions on Myanmar, the culmination of years of rapprochement that the US president has worked to facilitate.
The Southeast Asian nation, also known as Burma, has pursued political reforms over the last five years following decades of oppressive military rule.
Obama had announced plans to lift the sanctions last month, when Myanmar's new civilian leader, Nobel Peace Prize laureate Aung San Suu Kyi, visited the Oval Office.
Aung San Suu Kyi concurred it was time to remove all the sanctions that had hurt the economy and urged Americans to come to the country and "to make profits".
The US has already eased broad prohibitions on investment and trade but had retained more targeted restrictions on military-owned companies and officials and associates of the former ruling military government.
US companies and banks have remained leery of involvement in one of Asia's last untapped markets.
Friday's executive order lifts those restrictions. It removes the national emergency with respect to Myanmar - the executive order authorising sanctions that has been renewed annually by US presidents for two decades.
It also lifts a ban on the importation of jadeite and rubies from Myanmar and removes banking restrictions, the Associated Press reported.
"I have determined that the situation that gave rise to the national emergency with respect to Burma has been significantly altered by Burma's substantial advances to promote democracy, including historic elections in November 2015," Obama wrote in a letter to the leaders of Congress.
He said the US intends to use other means to support Myanmar in the "significant challenges" it still faces.
Some Myanmar nationals will remain on the Treasury Department's list of Specially Designated Nationals under other sanctions authorities, such as those intended to block the drug trade, a Treasury statement said.
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This bars them from any business dealings with the US. They include alleged drugs kingpin Wei Hsueh Kang and other figures from the United Wa State Army, one of Myanmar's biggest ethnic armed groups.
Among those taken off are ex-military government chief, Than Shwe, and the founder of one of the nation's largest conglomerates, Stephen Law, whose late father was once described by the Treasury as one of the world's key heroin traffickers.
Also taken off were military officials added to the blacklist since 2013 for alleged arms trading with North Korea, such as Lieutenant General Thein Htay, chief of the Directorate of Defence Industries.
Human rights groups have argued that lifting sanctions is premature as the US will lose leverage over Myanmar's powerful military. Despite the election victory by Aung San Suu Kyi party last year, the military still wields major political and economic influence.
Senator Ben Cardin, a top-ranking Democrat on the Senate Foreign Relations Committee, voiced support for the sanctions action, but concern over the plight of Rohingya Muslims, ethnic reconciliation and reform of a military-government-era constitution that guarantees the military a quarter of parliamentary seats.
"Even as we lift these sanctions we must maintain a focus on ongoing concerns regarding the role of the military in Burma's economy and politics," Cardin said in a statement, noting that Aung San Suu Kyi had raised the issue when she met senators during her Washington visit last month.
Obama's outreach to Myanmar has reflected his willingness to engage with American adversaries - others being Cuba and Iran. The administration has also sought to promote US strategic interests in Asia.