Philippine President Rodrigo Duterte has called Barack Obama a "son of a whore", saying that he will not be lectured by the US leader on human rights.
Duterte bristled at warnings he would face questioning by the US president at a scheduled meeting in Laos over a war against drugs in the Philippines that has claimed more than 2,400 lives in just over two months.
"You must be respectful. Do not just throw away questions and statements. Son of a whore, I will curse you in that forum," Duterte told a news conference shortly before flying to Laos to attend a summit on Monday.
"We will be wallowing in the mud like pigs if you do that to me."
Duterte was due to hold a bilateral meeting with Obama on Tuesday afternoon on the sidelines of a gathering of global leaders hosted by the Association of Southeast Asian Nations (ASEAN) in Vientiane, the capital of the Laos.
READ MORE: The Philippines, where bodies pile up, but no one talks
But shortly after Duterte spoke, Obama appeared to cast doubt on whether such a meeting could take place.
Calling Duterte "a colourful guy", the US president said he was asking his staff to find out whether a meeting would be useful.
"I always want to make sure if I'm having a meeting that it's actually productive and we're getting something done," he told reporters.
Duterte, 71, was elected in May after a promise to wage an unprecedented war on drugs.
INTERACTIVE: Death toll in Duterte's war on drugs
Official figures released on Sunday showed that, since he took office on June 30, over 2,400 people have been killed in police anti-drug operations and by suspected vigilantes.
Speaking on the sidelines of the G20 summit in the Chinese city of Hangzhou, Obama said Washington recognised that drugs were a significant problem for the Philippines.
But he also insisted that he would not shy away from raising concerns about the way the issue was being handled under the new administration.
"The issue of how we approach fighting crime and drug trafficking is a serious one for all of us. We've got to do it the right way," he said.
"Undoubtedly, if and when we have a meeting, this is something that's going to be brought up. And my expectation, my hope is that it could be dealt with constructively."
'More people will be killed'
Duterte has previously angrily rejected criticism from the Catholic Church, human rights groups, politicians and the United Nations.
"More people will be killed, plenty will be killed until the last pusher is out of the streets. Until the (last) drug manufacturer is killed, we will continue and I will continue," he said on Monday.
READ MORE: Philippines and Maoist rebels sign indefinite ceasefire
Duterte insisted he would not take orders from the US, a former colonial ruler of the Philippines, and did not care about how he was perceived.
Duterte has quickly earned a reputation for making offensive comments about his critics.