New England Patriots quarterback Tom Brady became just the fourth player to throw 400 career touchdown passes in the NFL.
Just before half-time, Brady found wide receiver Danny Amendola in the end zone from one yard as the reigning Super Bowl champion Patriots took control against the Jacksonville Jaguars.
The Patriots led the Jaguars 20-3 at the interval before rolling to a commanding 51-17 victory.
"It was a good day, so it's fun to be out there," Brady told reporters after completing 33 of 42 passes for 358 yards, two touchdowns and no interceptions as New England improved to 3-0.
"I think everyone enjoyed it. It was a good performance by our offence, a good team win. It was a good week of practise. A lot of guys made plays, so I was happy. It was a great day out there for football."
Peyton Manning of the Denver Broncos is the all-time NFL leader with 533 touchdown passes ahead of Sunday night's game against Detroit, followed by the retired Brett Favre (508) and Dan Marino (420).
A four-time Super Bowl champion with New England, Brady started this season after a federal judge overturned a four-game suspension imposed by the NFL for his alleged role in deflating footballs during a playoff game last season.
He has once again proved his value as one of the greatest quarterbacks of all time, guiding his team to a 3-0 start, and he received boisterous cheers from the Patriots crowd on Sunday as they repeatedly chanted his name.
Atlanta 39-28 Dallas
Indianapolis 35-33 Tennessee
Oakland 27-20 Cleveland
Cincinnati 28-24 Baltimore
New England 51-17 Jacksonville
Carolina 27-22 New Orleans
Philadelphia 24-17 NY Jets
Houston 19-9 Tampa Bay
Minnesota 31-14 San Diego
Pittsburgh 12-6 St Louis
Arizona 47-7 San Francisco
Buffalo 41-14 Miami
Seattle 26-0 Chicago
Denver 24-12 Detroit