Bayern Munich's Arjen Robben is out for the season after tearing a muscle in their German Cup semi-final defeat by Borussia Dortmund on Tuesday while Robert Lewandowski broke his jaw and nose and suffered concussion.
The injuries come days before Bayern travel to Barcelona for next week's Champions League last-four clash, dealing a major blow to their hopes of lifting the trophy on home soil with the final scheduled to be played in Berlin in June.
"Robben suffered a torn muscle in his left calf and his season is over after only making his comeback against Dortmund," Bayern said in a statement on Wednesday.
The Dutchman, who had a stellar season, scoring 17 league goals until his injury in March, lasted just 16 minutes as a second half substitute for the injured Thiago Alcantara.
Meanwhile, Lewandowski, who was knocked down in a rough challenge by Dortmund goal-keeper Mitch Langerak, broke his upper jaw and nose and suffered concussion.
The in-form Poland striker had scored nine goals in his last 11 matches for the Bavarians, who secured the Bundesliga title last week with four games to spare.