The Miami Heat first lost shooting guard Dwyane Wade to a right hamstring injury in the third quarter, then lost the game altogether as the Milwaukee Bucks prevailed 109-102.
Milwaukee, which outscored the Heat in bench points by a 54-15 margin, improved to 3-0 against Miami this season.
Wade's injury marks the third time he has hurt one of his hamstrings this season. He missed seven games in November with a left hamstring injury and was out for two games earlier this month with the same injury.
Elsewhere, John Wall had 21 points, 13 assists and nine rebounds, leading the Washington Wizards to a 98-92 victory over the Los Angeles Lakers.
Bradley Beal scored 19 points for the Wizards, who won their second straight. Washington (31-15) prevailed without starting forward Paul Pierce, who missed the game due to a sore right big toe.
The Lakers played without guard Nick Young, who sustained a right ankle sprain in practice on Monday. They already lost guard Kobe Bryant, who will miss the rest of the season with a torn right rotator cuff.
Cavaliers 103, Pistons 95
Bulls 113, Warriors 111 (OT)
Grizzlies 109, Mavericks 90
Raptors 104, Pacers 91