Indian leaders have celebrated the eradication of polio, reminding doubters that something once thought impossible had been achieved and promising to tackle other diseases which still blight the country.
In January, the country of 1.2 billion people marked three years without a new case of the crippling virus, which means it will soon be certified as having wiped out the scourge.
At a function attended by the president and other dignitaries, Prime Minister Manmohan Singh thanked the more than two million vaccinators who criss-crossed the country to help bring about the milestone.
"It is a day we have worked for tirelessly and awaited anxiously. Now it has dawned, it gives us great pride," Singh told an audience in a New Delhi stadium.
His speech came on the same day Afghanistan announced a three-year-old girl from Kabul had contracted polio, the capital's first case since the Taliban were ousted in 2001.
Polio is a virus spread through faecal matter that affects the central nervous system and can leave its victims with withered limbs, paralysed or dead.
There is no cure but it can be prevented through mass vaccination programmes which target the under-fives.
'Serve as an example'
India's poor sanitation, mass internal migration and dilapidated public health system made many experts believe it would be the last country to eradicate the disease, if at all.
"I sincerely hope that what we have been able to do will serve as an example and give the global community confidence that polio will be erased from the face of the earth in the same way as smallpox," Singh said.
"It is our duty to follow the path laid by this programme to other (public health) areas," he added.
There are now only three countries where polio is endemic - Pakistan, Afghanistan and Nigeria - and health workers say steady progress is being made towards global eradication.
Isolated polio outbreaks in the Horn of Africa and war-racked Syria emerged as new causes for concern in 2013, however, and polio vaccination workers in Pakistan are still being killed by the Taliban.
The head of the World Health Organisation (WHO), Margaret Chan, said that India had proved its doubters wrong.
"India has shown to the world that there is no such thing as impossible," she said.
India reported 150,000 cases of paralytic polio in 1985 and still accounted for half of all cases globally in 2009, with 741 infections that led to paralysis.
In 2010 the number of victims fell to double figures before the last case on January 13, 2011, when an 18-month-old girl in a Kolkata slum was found to have contracted it.
The girl, Rukshar Khatoon, is now attending school and leads a "normal life", although she still suffers pain in her right leg, doctors and her parents have told AFP.
Official certification by the WHO that India has eradicated polio is likely to come at the end of next month.