Mohamad Bani Odah was shot dead by Israeli forces who opened fire at a group of Palestinians throwing stones at them in the village of Tamoon, south of the city of Ramallah, Palestinian security sources said on Sunday.
Several other Palestinians were injured in the clashes, including two in a serious condition.
An Israeli army spokesperson confirmed that the army had entered the village with about 20 vehicles and arrested a member of the Islamic Jihad group, after which the clashes erupted.
"During the clashes, Palestinians threw stones, Molotov cocktails, explosive devices and fired on the force which in reaction opened fire and identified hitting several people," the spokesperson said.
The latest deaths bring to 5,444 the number of people killed since the start of the second Palestinian uprising in September 2000, the vast majority of them Palestinians, according to an Associated French Press count.