Ahmadinejad also questioned Israel's right to exist. "This is a fake regime ... it won't be able to survive. I think the only way (forward) is that those who created it (the West) take it away themselves," the president told a rally in Tehran in support of Palestinians.
Ahmadinejad, who last year called for Israel to be "wiped off the map," has repeatedly voiced fiery rhetoric against the Jewish state.
The Islamic republic's president joined thousands of demonstrators in the capital on Friday to condemn the Israeli strikes, and said Israel's Western supporters could be the target of revenge by Muslims.
"They should not let things reach a point where an explosion occurs in the Islamic world," he said.
"If an explosion occurs, then it won't be limited to geographical boundaries. It will also burn all those who created (Israel) over the past 60 years," he said, implicitly referring to the United States and other Western nations who support Israel.