The 10-year-old girl surnamed Tang from Ziyuan County in the Guangxi Zhuang Autonomous Region developed fever and pneumonia-like symptoms on 23 November, the report said on Tuesday, adding that the ministry of health had confirmed the case.
Tests showed she was H5N1 positive, the agency said quoting China's Centre for Disease Control and Prevention.
It is the fourth confirmed human case of bird flu reported in China which has reported two deaths from the virus.
China has seen at least 30 outbreaks of bird flu in 11 provinces and regions this year, with nine of them in Xinjiang, according to the China Daily.
Bird flu has killed more than 60 people in Southeast Asia since 2003.