The Michael Moore documentary Fahrenheit 9/11, which took a critical look at US President George Bush's actions after the September 11 attacks, won the favourite movie award on Sunday, while Mel Gibson's The Passion of the Christ won in the favourite drama category.
Moore dedicated his win to the US troops fighting overseas and said he was "amazed" that people voted his film their favourite.
"I love making movies and I'll take this as an invitation to make more Fahrenheit 9/11s," he said.
Gibson echoed Moore's appreciation, saying the award "means a lot more to me this time than anything before".
"I depended on you and you were there," Gibson said. "If it wasn't for you guys, we would have been dead in the water."
The animated Shrek 2 swept a number of categories, being named favourite comedy, favourite sequel and favourite animated movie.
The character of Donkey in Shrek 2, voiced by Eddie Murphy, was named favourite animated movie star, while the Fairy Godmother, voiced by Jennifer Saunders, won in the favourite movie villain category.
Perennial favourites took many of the top awards, including many of this year's new categories. Julia Roberts and Johnny Depp won for favourite female and male movie star. Matt LeBlanc and Marg Helgenberger won for favourite male and female TV stars.
"If it wasn't for you guys, we would have been dead in the water"
US director and actor
Will & Grace won for favourite TV comedy and CSI: Crime Scene Investigation was named favourite TV drama.
After votes cast via the internet during the first hour of the live telecast were counted, Joey was named favourite new TV comedy, while Desperate Housewives won for favourite new TV drama.
The People's Choice Awards, hosted by Jason Alexander and Malcolm-Jamal Warner, were presented at the Pasadena Civic Auditorium and broadcast on CBS.
The awards covered 38 film, television and music categories.
The nominations were determined by editors at Entertainment Weekly, the People's Choice production team and a panel of pop culture fans.
Winners were determined by internet voting.