Aljazeera's correspondent reported that among those detained were relatives of Zakaria al-Zubaidi, leader of the Jenin wing of the al-Aqsa Martyrs Brigades, a resistance movement.
The Israeli army, with about 50 military vehicles backed by helicopters, invaded in the early hours of Tuesday and announced a curfew over loudspeakers.
The army also called on al-Zubaidi to surrender. Troops stormed his relatives' homes and demanded they hand him over.
Despite the raid and search operation, al-Zubaidi has not been captured, Aljazeera's correspondent said.
Clashes also erupted between the resistance movement's fighters and Israeli occupation forces.
Several Palestinians were beaten during the raid.
The occupation forces also detained relatives of deceased resistance fighters, such as those of Mahmud Abu Khalifa, al-Zubaidi's close aide, who was assassinated by Israel a few days ago, the correspondent added.
The army also targeted the home of Adnan al-Hindi, a prominent leader of Yasir Arafat's Fatah faction and head of the Popular Committee for Services in Jenin's refugee camp.
The army, which frequently raids Palestinian territories saying they are hunting wanted Palestinian activists, has begun to withdraw from the area and has lifted the six-hour curfew.