Police on Thursday escorted the woman Sue Niederer from a rally at a fire hall in Hamilton, New Jersey, after she demanded to know why her son, 1st Lieutenant Seth Dvorin, 24, was killed in Iraq.
Dvorin died in February while trying to disarm a bomb.
As shouts of "four more years" subsided, Niederer, standing in the middle of a crowd of some 700, continued to shout about the killing of her son.
Secret service and local police escorted her out of the event, handcuffed her and placed her in the back of a police van.
Laura Bush continued speaking, touting her husband's record on the economy, health care and the "war on terror" to those attending the rally in this suburban community of 90,000 people near Trenton.
"President Bush You Killed My Son"
slogan on T-shirt of dead US soldier's mother
She made several references to the 11 September 2001 attacks, and noted that many in New Jersey, including some in neighbourhoods near the firehall, lost family members that day.
"Too many people here had a loved one that went to work in New York that day," Bush said.
"It's for our country; it's for our children, our grandchildren that we do the hard work of confronting terror," she said.