A gift from one of the most famous sports car manufacturers, the blue and white vehicle was presented complete with flashing blue lights and a siren.
With a top speed of 309kph, it should have the edge in any chase on the Salerno-Reggio Calabria motorway.
However, the car is just as likely to be used for emergency deliveries such as human organs for transplant.
The sleek two-seater was put on display in Rome at a police event before entering service on the notorious motorway in the south.
It is a six-speed luxury vehicle with a 500-horsepower engine designed to go from zero to 100kph in four seconds.
Donated by the Lamborghini factory in Bologna, its list price is $165,000, probably making it unlikely that the Italian police force will actually buy any for its fleet.