The two day sweep in Ramadi on Saturday and Sunday led to the discovery of a few bombs and the arrest of some resistance fighters.
But it also resulted in a large number of injuries, though a US army spokeswoman declined to give details.
However, a US military statement confirmed the casualties were from Task Force All American and the US Marines during an operation 100kms west of Baghdad.
"Soldiers discovered and disarmed five improvised explosive devices before they could be detonated and captured seven enemy personnel," the statement said.
Task Force All American, which groups the 82nd Airborne Division and the 3rd Armored Cavalry Regiment, also raided the town of Musayyib to arrest resistance ringleaders.
The raid resulted in the detention of four individuals.
Three US soldiers were also wounded in a bomb attack on Friday, one of them seriously, the statement said.
Meanwhile, four civilians were wounded when fighters launched mortars at Abu Ghuraib prison on the western edge of Baghdad and one bomb hit a neighbouring apartment complex.
The high number of casualties over the weekend brings the total number of US-led forces wounded during Iraq's invasion and occupation to more than 3200.
A total of 564 soldiers have died in the same period, according to US Central Command and the US Department of Defence.