Bush had just finished speaking at Southhaven, Mississippi, on Saturday, when the car, chased by several police cars, broke through the security perimeter and slammed into the building just before Bush's departure.
The car crossed a parking lot and headed for a loading dock ramp. But the driver missed the ramp and crashed into an exterior wall.
The driver immediately got out and was taken into custody. Witness reported that the car was driven by a woman with two children in the car.
The incident delayed the president's departure, but he was unhurt and later seen waving to reporters before boarding Air Force One.