Yuri Malenchenko, a cosmonaut circling 380 km above the earth, married his fiance Yekaterina Dmitriev who was in Texas on Sunday.
Peering into each other's eyes via a satellite video hook-up at the Johnson Space Centre, the two exchanged vows before 200 people.
The ceremony ended with the Russian bride blowing her Ukrainian husband a long-distance kiss.
A beaming Dmitriev, dressed in a traditional white wedding dress, said she was very happy even though she would not see Malenchenko, 41, until he returned to earth in early November.
"It was cool - it went straight to the heart," she said, standing next to a life-size cutout of Malenchenko that was his stand-in at the reception.
Friend Harry Noe stood in as the groom's proxy, which is permitted under Texas law, and gave the 26-year old Dmitriev her ring.
Stars in her eyes ... bride Dmitriev
At the same time, Malenchenko, who wore a bow tie with his flight suit, slipped on a ring his new bride had shipped to his space station.
However, Malenchenkio's "space wedding" may have landed him in trouble with his parents.
Nina and Ivan Malenchenko only found out about his unorthodox nuptials at the last minute.
After speaking to their son on Saturday, his parents said he mentioned little about the wedding.
"We do not understand this and think it should not be like this. It's strange because the groom will not be at his own wedding," Nina Malenchenko said.