The increasing use of suicide bombers - often young women and girls forced to carry and detonate explosives in crowded areas - has killed at least 381 civilians in the two countries, Amnesty International group said in a statement on Tuesday.
"Boko Haram is once again committing war crimes on a huge scale, exemplified by the depravity of forcing young girls to carry explosives with the sole intention of killing as many people as they possibly can," said Alioune Tine, Amnesty International's director for West and Central Africa.
"This wave of shocking Boko Haram violence, propelled by a sharp rise in suicide bombings, highlights the urgent need for protection and assistance for millions of civilians ... Governments in Nigeria, Cameroon and beyond must take swift action to protect them from this campaign of terror."
Amnesty said at least 223 civilians died in Nigeria since April, underscoring that the real toll could be far higher.
"Between May and August, seven times more civilians were killed than in the preceding four months, while 100 civilians were killed in August alone," it said.
"The recent spike in casualties has been driven by increased suicide attacks, with 30 - more than one per week - carried out since the beginning of April," it said.
The deadliest attack took place in the town of Waza on July 12 when 16 civilians were killed and at least 34 injured after a young girl was forced to carry and detonate a bomb in a crowded video game centre.
The group initially claimed to be fighting for the creation of an Islamic state in the north, but a range of demands by different people have since been issued.
At least 20,000 people have been killed in violence since 2009 and more than 2.6 million people have been left homeless.
More than five million people are starving as the fighting has devastated farmland, leaving farmers unable to sow or cultivate crops for several years.
The violence and security situation in the region has also forced thousands of parents not to send their children to schools.
Source: News agencies